Randomized Trialhigh evidence
Direct His/LBB Pacing as an Alternative to Biventricular Pacing in Patients With HFrEF and a Typical LBBB: The His-Alternative II Study.
JACC. Clinical electrophysiology·August 21, 2026·PMID 42671372
Why it mattersConduction system pacing offers a more physiologic alternative to biventricular pacing for cardiac resynchronization, potentially avoiding coronary sinus lead limitations. This trial provides randomized evidence that CSP-CRT achieves comparable reverse remodeling and clinical benefits in a typical CRT-eligible population.
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