Randomized Trialhigh evidence
Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.
American journal of physiology. Endocrinology and metabolism·August 1, 2026·PMID 42314769
Why it mattersTMAO is often cited as a cardiometabolic risk factor, but its direct role in insulin resistance is unclear. This study challenges the causal narrative, helping clinicians contextualize TMAO-focused dietary advice for metabolic health.
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