Randomized Trialhigh evidence
Differential Effects of Blood-Flow Restriction and High-Intensity Resistance Training on Cortical Thickness and White Matter Integrity in Older Men: A Three-Group Randomized Controlled Trial.
Brain sciences·July 28, 2026·PMID 42651108
Why it mattersResistance training may support brain health in aging, but the optimal modality is unclear. This trial suggests HIRT and BFRT affect different neural substrates—cortical thickness versus white matter microstructure—offering potential for targeted exercise prescriptions to preserve cognitive function.
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