Cohort Studyhigh evidence
Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study.
The Lancet. Respiratory medicine·July 1, 2026·PMID 42140220
Why it mattersReal-time identification of hyperinflammatory versus hypoinflammatory subphenotypes in ARDS could enable precision medicine trials and targeted therapies, potentially improving outcomes in a condition with high mortality.
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