Randomized Trialhigh evidence
Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer.
The New England journal of medicine·May 31, 2026·PMID 42223072
Why it mattersThis is the first phase 3 trial to show a substantial survival benefit with a RAS-targeted therapy in pancreatic cancer, where >90% of tumors harbor RAS mutations and current options are limited.

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