Randomized Trialhigh evidence

Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer.

The New England journal of medicine·May 31, 2026·PMID 42223072

Why it matters

This is the first phase 3 trial to show a substantial survival benefit with a RAS-targeted therapy in pancreatic cancer, where >90% of tumors harbor RAS mutations and current options are limited.

Infographic summary of Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer.
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