Randomized Trialhigh evidence
The effect of hormone therapy on vaginal microbiota in women with genitourinary syndrome of menopause: A double-blind, randomized, placebo-controlled trial.
Maturitas·June 1, 2026·PMID 42097107
Why it mattersIt clarifies that systemic MHT’s clinical benefits for GSM are not dependent on restoring a lactobacillus-dominant vaginal microbiome, which may influence counseling about expected mechanisms and timing of symptom relief.
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