Cohort Studyhigh evidence
Joint impact of pathological burden and cognitive resilience on Alzheimer's disease risk.
Nature medicine·September 11, 2026·PMID 42728380
Why it mattersAlzheimer's risk is not solely determined by amyloid and tau burden; cognitive resilience independently and synergistically shapes dementia risk. This dual-dimension model may improve risk stratification and supports interventions that enhance resilience alongside pathology reduction.
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