Randomized Trialhigh evidence
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials.
JAMA·March 10, 2026·PMID 41505155
Why it mattersIbuprofen monotherapy is standard for pediatric musculoskeletal pain, but many children have inadequate relief. This high-quality evidence clarifies that common add-on analgesics offer no additional benefit and that opioids increase harm without improving analgesia.
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