Meta-Analysishigh evidence
Comparative efficacy of positive airway pressure-based combination therapy in comorbid insomnia and sleep apnea: A systematic review and network meta-analysis.
Sleep medicine reviews·August 1, 2026·PMID 42107468
Why it mattersCOMISA is common and challenging to treat. This analysis clarifies which PAP-based combinations most effectively target both insomnia and sleepiness, guiding multimodal treatment selection beyond PAP alone.
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