Basic Sciencemoderate evidence
Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)·May 1, 2026·PMID 41747076
Why it mattersIt identifies a muscle-to-bone endocrine pathway that may explain bone loss in sarcopenia and aging, offering a potential therapeutic target for osteoporosis in frail older adults.
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