Cohort Studyhigh evidence
Etomidate Is Associated with Higher 30-Day Mortality than Ketamine for Emergency Intubation of COVID-19 Patients: A Propensity-Matched Cohort Study.
Journal of clinical medicine·June 29, 2026·PMID 42452512
Why it mattersCOVID-19 patients may have adrenal vulnerability that amplifies etomidate-induced adrenal suppression, potentially increasing mortality. This study provides evidence that ketamine may be a safer induction agent for emergency intubation in this population, challenging the common use of etomidate in critically ill patients.
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