Randomized Trialhigh evidence
Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial.
Pain·November 1, 2025·PMID 40359364
Why it mattersNeuropathic pain is often worse at night and associated with sleep disturbance, and safe nonopioid treatments are needed. Despite preclinical and observational signals suggesting melatonin might reduce pain, this well-designed trial found no analgesic benefit over placebo, helping clinicians avoid ineffective therapy.
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