Comment on: Cardiovascular and prostate cancer risk associated to testosterone replacement therapy - a systematic review and meta-analysis of 41 randomized controlled trials.

International journal of impotence research·July 23, 2026·PMID 42493582

Why it matters

Testosterone replacement therapy is widely used for hypogonadism, yet concerns persist about its cardiovascular and prostate safety. A comprehensive meta-analysis of RCTs provides the highest level of evidence to inform risk-benefit discussions, directly impacting prescribing decisions in hormone health and longevity practices.