Meta-Analysishigh evidence
Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic Review and Meta-Analysis.
Brain and behavior·August 1, 2026·PMID 42518172
Why it mattersTandem lesions present a treatment dilemma, and current guidelines lack clear recommendations on bridging IV thrombolysis before endovascular therapy. These findings suggest a potential benefit of combined therapy in improving outcomes without increasing hemorrhage risk, informing decision-making in acute stroke care.
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