Guidelinehigh evidence
Focused Update to International Consensus Recommendations for the Use of Prolonged-Infusion Beta-Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists.
Pharmacotherapy·September 1, 2026·PMID 42598847
Why it mattersSeverely ill patients with serious infections may have better survival and clinical cure with prolonged-infusion beta-lactams, a simple dosing strategy change. This update incorporates new RCTs, increasing certainty and providing stronger evidence for critical care and internal medicine clinicians to adopt this practice.
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