Meta-Analysishigh evidence
Cefepime and Mortality: A Systematic Review and Bayesian Meta-Analysis.
JAMA network open·September 1, 2026·PMID 42720951
Why it mattersCefepime is widely used for febrile neutropenia and serious gram-negative infections, yet its safety relative to other β-lactams has been debated. This meta-analysis provides the most comprehensive evidence to date, suggesting a small but consistent mortality risk that may influence antibiotic selection and guideline discussions.
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