Randomized Trialhigh evidence
Mediators of treatment response in a clinical trial of naltrexone and bupropion for methamphetamine use disorder: A longitudinal mediation analysis.
Journal of psychopharmacology (Oxford, England)·July 26, 2026·PMID 42504048
Why it mattersIdentifying craving as a key mediator clarifies how naltrexone-bupropion works in methamphetamine use disorder, supporting craving as a surrogate endpoint in future trials and a target for clinical monitoring.
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