Meta-Analysishigh evidence
Catheter-Based Left Atrial Appendage Closure vs Oral Anticoagulation in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis.
JAMA cardiology·August 26, 2026·PMID 42646743
Why it mattersStroke prevention in atrial fibrillation requires balancing thromboembolic and bleeding risks. LAAC offers a mechanical alternative for patients unsuitable for long-term OAC, but its efficacy relative to OAC has been uncertain. This analysis clarifies that LAAC does not reduce overall stroke and may increase ischemic stroke, while reducing bleeding after the procedure.
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