Meta-Analysismoderate evidence
Platelet Concentration Is Not Associated With Improved Pain for Partial-Thickness Rotator Cuff Tears Treated With Platelet-Rich Plasma: A Systematic Review and Meta-analysis With Meta-regression of Level 1 Randomized Controlled Trials.
Orthopaedic journal of sports medicine·September 1, 2026·PMID 42729508
Why it mattersPRP is widely used for partial-thickness rotator cuff tears, but optimal platelet dosing remains unclear. This analysis suggests that simply increasing platelet concentration beyond a 4-fold threshold does not improve pain relief, guiding clinicians away from assuming higher doses are more effective.
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