Cohort Studyhigh evidence
Twenty-Five-Year Follow-Up of Quantified Mitral Regurgitation.
JAMA cardiology·July 29, 2026·PMID 42525396
Why it mattersCurrent guidelines focus on severe MR, but the optimal management of moderate MR remains uncertain. This study provides long-term data suggesting that surgical intervention may confer a survival benefit even in asymptomatic patients with upper-moderate MR, potentially informing earlier referral thresholds.
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