Meta-Analysishigh evidence
Dose-response effects and mechanistic pathways linking physical exercise to brain volume and cognition: a systematic review and meta-analysis of randomized controlled trials.
European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·January 5, 2026·PMID 41491407
Why it mattersIt provides dose-response evidence that exercise preserves brain volume in aging, linking specific exercise parameters to cognitive benefits. This helps clinicians tailor exercise prescriptions for brain health.

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