Meta-Analysishigh evidence

Dose-response effects and mechanistic pathways linking physical exercise to brain volume and cognition: a systematic review and meta-analysis of randomized controlled trials.

European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity·January 5, 2026·PMID 41491407

Why it matters

It provides dose-response evidence that exercise preserves brain volume in aging, linking specific exercise parameters to cognitive benefits. This helps clinicians tailor exercise prescriptions for brain health.

Infographic summary of Dose-response effects and mechanistic pathways linking physical exercise to brain volume and cognition: a systematic review and meta-analysis of randomized controlled trials.
Visual abstract · MedLit

The papers that matter, first.

MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.

§

MedLit · Evidence, Distilled