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Muscle Mitochondrial Oxidative Capacity and Cognitive Decline Over up to a Decade: Sex Differences.

Aging cell·August 1, 2026·PMID 42479929

Why it matters

Muscle mitochondrial health may serve as a window into brain aging, but its predictive value for cognitive decline appears sex-dependent. For clinicians focused on aging and cognitive performance, these findings suggest that mitochondrial assessments could help stratify cognitive risk in older men, while highlighting distinct biological pathways that may inform targeted interventions.

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