Basic Sciencelow evidence
Mitochondrial DNA leakage in oocytes activates cGAS-STING signaling to drive ovarian aging.
Nature aging·August 28, 2026·PMID 42665751
Why it mattersOvarian aging is a central driver of systemic aging, yet its molecular triggers are poorly defined. This work identifies a specific, targetable mechanism—mtDNA leakage activating cGAS-STING—that causally contributes to ovarian decline, offering a potential therapeutic avenue for preserving ovarian function and delaying age-related comorbidities.
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