Randomized Trialhigh evidence
Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial.
JAMA·December 2, 2025·PMID 41076587
Why it mattersIntraoperative hypotension is common and linked to postoperative complications, but evidence for proactive, risk-stratified MAP targeting has been lacking. This large, multicenter RCT provides high-quality evidence that such a strategy does not reduce functional disability or other outcomes compared to standard care.
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