Randomized Trialhigh evidence
Testosterone Treatment and Fractures in Men with Hypogonadism.
The New England journal of medicine·January 18, 2024·PMID 38231621
Why it mattersThis is the first large, long-term RCT to assess fracture outcomes with testosterone therapy in hypogonadal men. The counterintuitive increase in fractures demands attention from clinicians prescribing testosterone for bone health, especially in men with cardiovascular comorbidities.
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