Basic Sciencemoderate evidence
Digestion-resistant proteins support the healthy metabolite profiles associated with plant-based diets.
Proceedings of the National Academy of Sciences of the United States of America·August 11, 2026·PMID 42507910
Why it mattersPlant-based diets are linked to better health and a diverse gut microbiome, but the mechanisms behind their metabolic benefits are unclear. This study identifies how specific dietary components—fiber and digestion-resistant protein—cooperatively shape microbial phenol production, offering mechanistic targets for nutritional interventions aimed at reducing uremic toxins and boosting beneficial metabolites.
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