Basic Sciencemoderate evidence
Mitochondrial metabolism and epigenetic crosstalk drive SASP.
Nature·July 29, 2026·PMID 42527602
Why it mattersSenescent cell-driven inflammation is a hallmark of aging and contributes to age-related tissue dysfunction. This work uncovers a metabolic checkpoint that selectively governs the inflammatory output of senescent cells, offering a potential therapeutic target for modulating aging-related inflammation without eliminating senescent cells entirely.
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