Younger age and platelet-rich plasma characteristics influence short-term outcomes in knee osteoarthritis, but independent effects remain uncertain: A systematic review with meta-analysis and meta-regression of placebo-controlled randomised trials.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·August 17, 2026·PMID 42605960

Why it matters

Knee osteoarthritis is a common, disabling condition with limited disease-modifying options. PRP is widely used but formulation varies greatly, and clinicians lack guidance on which patients or PRP types are most likely to benefit. This analysis helps identify potential predictors of response, such as younger age and specific PRP features, which can inform patient selection and product choice in clinical practice.