Randomized Trialhigh evidence
Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial.
Addiction (Abingdon, England)·June 22, 2026·PMID 42331724
Why it mattersPreventing progression from risky opioid use to OUD is a critical gap in primary care. This trial suggests that a collaborative care model may reduce OUD development, even if it does not immediately reduce use days, offering a potential preventive strategy for high-risk patients.

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