Basic Sciencemoderate evidence

Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis.

Neuron·September 29, 2026·PMID 42810344

Why it matters

Cervical lymphadenectomy is a common procedure in head and neck cancer, yet its potential impact on brain lymphatic clearance and cognition has been largely overlooked. These findings suggest that acute disruption of meningeal lymphatic drainage may trigger a specific biochemical cascade leading to cognitive decline, which could inform surgical decision-making and post-operative monitoring.

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