Randomized Trialhigh evidence
Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange.
Aging cell·August 1, 2025·PMID 40424097
Why it mattersThis is the first multi-omics RCT to show that a plasma-based intervention can reverse epigenetic aging clocks in healthy older adults, with coordinated molecular and immune improvements. It provides early evidence for a potential longevity intervention and highlights biomarkers that may guide patient selection.
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