Randomized Trialhigh evidence

Fecal microbiota transplantation-based treatment protocol for chronic insomnia disorder: A randomized, double-blind, placebo-controlled trial.

Journal of internal medicine·July 22, 2026·PMID 42482568

Why it matters

Chronic insomnia is prevalent and often inadequately managed with current therapies. This trial provides high-level evidence that gut microbiome modulation via FMT can improve both objective and subjective sleep measures, offering a novel therapeutic avenue for specialists managing sleep disorders or exploring gut-brain axis interventions.

Infographic summary of Fecal microbiota transplantation-based treatment protocol for chronic insomnia disorder: A randomized, double-blind, placebo-controlled trial.
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