Randomized Trialhigh evidence
Fecal microbiota transplantation-based treatment protocol for chronic insomnia disorder: A randomized, double-blind, placebo-controlled trial.
Journal of internal medicine·July 22, 2026·PMID 42482568
Why it mattersChronic insomnia is prevalent and often inadequately managed with current therapies. This trial provides high-level evidence that gut microbiome modulation via FMT can improve both objective and subjective sleep measures, offering a novel therapeutic avenue for specialists managing sleep disorders or exploring gut-brain axis interventions.

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