Randomized Trialhigh evidence
The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A Randomized Double-Blind Controlled Crossover Clinical Trial.
Nutrients·April 30, 2026·PMID 42124050
Why it mattersAnabolic resistance contributes to sarcopenia, and optimizing protein feeding strategies is clinically relevant. This study provides early evidence that older women may require adjunctive HMB to maximize muscle protein synthesis from high-dose protein, potentially informing personalized nutrition interventions.
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