Randomized Trialhigh evidence
Quantifying immune dysregulation in pneumonia and sepsis with a parsimonious machine-learning model: a multicohort analysis across care settings and reanalysis of a hydrocortisone randomised controlled trial.
The Lancet. Respiratory medicine·April 1, 2026·PMID 41856148
Why it mattersCurrent sepsis trials enroll based on clinical severity, which poorly reflects immune dysregulation. This tool offers a biologically informed method to identify patients most likely to benefit from immunomodulation, potentially reducing treatment heterogeneity and improving precision in critical care.
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