Meta-Analysishigh evidence
Novel β-Lactam/β-Lactamase Inhibitors Versus Best Available Therapy on the Mortality-Related Carbapenem-Resistant Enterobacterales Infection: A Systematic Review and Meta-Analysis.
Antibiotics (Basel, Switzerland)·September 18, 2026·PMID 42792078
Why it mattersCarbapenem-resistant Enterobacterales infections carry high mortality and limited treatment options. This analysis clarifies which BL/BLI agent to choose based on resistance mechanism, supporting a precision medicine approach guided by rapid molecular diagnostics. It also highlights the urgent need for new agents against metallo-β-lactamase producers.
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