Cohort Studyhigh evidence
Multimodal brain-gut-sleep phenotypes predict delirium, long-term cognitive decline, and survival after colorectal cancer surgery.
Psychoneuroendocrinology·May 1, 2026·PMID 41690125
Why it mattersPreoperative vulnerability to delirium, cognitive decline, and reduced survival after major cancer surgery is not random but reflects coordinated dysregulation across circadian, gut-brain, autonomic, and inflammatory systems. Identifying these phenotypes could enable targeted prehabilitation and risk stratification.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled