Randomized Trialhigh evidence
Physiological limits of capillary refill time: a human endotoxemia study.
Critical care (London, England)·August 31, 2026·PMID 42706575
Why it mattersCapillary refill time is a common bedside perfusion marker, but its reliability during acute inflammation is unclear. This study shows that a single qCRT value against a fixed 3-s threshold can be misleading, as values change dramatically over time and are heavily influenced by skin temperature. Clinicians should interpret CRT trends rather than isolated measurements.
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