Randomized Trialhigh evidence

Superficial parasternal intercostal plane block with ropivacaine versus placebo for opioid exposure after cardiac surgery (EPOCH CardioLink-10): a multicentre, double-blind, randomised trial.

Lancet regional health. Americas·August 1, 2026·PMID 42256617

Why it matters

This trial provides robust evidence for a specific opioid-sparing regional technique in cardiac surgery, where multimodal analgesia options are limited and opioid reliance remains high. The SPIP block offers a pragmatic, low-risk intervention to reduce opioid exposure without worsening pain control.

Infographic summary of Superficial parasternal intercostal plane block with ropivacaine versus placebo for opioid exposure after cardiac surgery (EPOCH CardioLink-10): a multicentre, double-blind, randomised trial.
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