Randomized Trialhigh evidence
Opioid-free analgesia with esketamine-dexmedetomidine versus opioid-based analgesia after gynaecological laparoscopic surgery: a double-blind, randomized, controlled trial.
Annals of medicine·December 1, 2026·PMID 42745658
Why it mattersPostoperative opioid use often causes dizziness, nausea, and vomiting with limited benefit for recovery quality. An effective opioid-free regimen could reduce opioid-related adverse effects and improve patient comfort after gynecological laparoscopic surgery.
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