Cohort Studyhigh evidence
Multi-omic profiling reveals age-related immune dynamics in healthy adults.
Nature·December 1, 2025·PMID 41162704
Why it mattersIt uncovers specific, early immune aging mechanisms—particularly a TH2 shift in memory T cells—that may explain reduced vaccine efficacy in older adults, even before advanced age. This offers potential targets for immune modulation and informs vaccine strategies.
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