Cohort Studyhigh evidence

Adolescent Cardiorespiratory Fitness and the Trade-Off Between Atrial Fibrillation Risk and Cardiovascular Benefits: A Nationwide Sibling-Controlled Cohort Study.

Circulation·July 7, 2026·PMID 42165142

Why it matters

Concerns about AF risk in highly fit individuals may deter exercise promotion. This study clarifies that familial confounding explains much of the observed AF excess, and high adolescent fitness yields net cardiovascular benefit, supporting youth fitness initiatives.

Infographic summary of Adolescent Cardiorespiratory Fitness and the Trade-Off Between Atrial Fibrillation Risk and Cardiovascular Benefits: A Nationwide Sibling-Controlled Cohort Study.
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