Basic Sciencelow evidence
Exercise alleviates neuroinflammation and cognitive decline in aged mice via hepatic FGF21-driven microglial mitophagy.
Brain, behavior, and immunity·July 30, 2026·PMID 42532442
Why it mattersAging-related cognitive decline is linked to neuroinflammation, and exercise is a known protective factor. This study uncovers a liver-to-brain signaling pathway involving FGF21 and mitophagy that may explain how physical activity preserves brain health in aging, offering potential mechanistic targets for interventions.
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