Randomized Trialhigh evidence
Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial.
BMJ (Clinical research ed.)·July 29, 2026·PMID 42526943
Why it mattersMigraine patients with PFO may benefit from antithrombotic therapy, but evidence has been limited. This trial provides head-to-head data showing rivaroxaban's superiority over a standard preventive (metoprolol), suggesting a potential role for anticoagulation in this subgroup.
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