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Multidimensional integrative analysis unveils genetic architecture, risk factors, and health consequences of brain aging.

Journal of advanced research·February 17, 2026·PMID 41713737

Why it matters

Brain-age-gap is emerging as a composite biomarker of brain health. This study clarifies its genetic architecture and links to modifiable factors and systemic disease, offering a framework for risk stratification and prevention in aging populations.

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