Randomized Trialhigh evidence
Emergency Department-initiated standard versus high-dose buprenorphine induction (ENVISION): a randomised clinical trial protocol.
BMJ open·June 3, 2026·PMID 42236100
Why it mattersEmergency physicians frequently initiate buprenorphine for OUD, but the optimal induction dose is unknown. This trial will provide the first prospective evidence comparing standard and high-dose strategies, potentially influencing ED protocols and improving linkage to care.
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