Randomized Trialhigh evidence
A Synthetic Form of Cannabinoid Does Not Decrease Opioid Use After Total Knee Arthroplasty: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Study.
The Journal of arthroplasty·March 31, 2026·PMID 41967982
Why it mattersCannabis use is increasingly common in surgical patients, but high-quality evidence on its analgesic efficacy is lacking. This study provides robust data that a specific synthetic THC formulation does not reduce opioid needs after TKA, helping clinicians counsel patients and avoid ineffective treatments.
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