Randomized Trialhigh evidence
Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome.
The Journal of clinical endocrinology and metabolism·March 17, 2026·PMID 41160096
Why it mattersMetformin is widely prescribed for hyperglycemia and cardiovascular risk reduction, yet this trial suggests it may counteract key vascular and metabolic adaptations to exercise training—raising important considerations for clinicians managing patients who combine pharmacotherapy with lifestyle interventions.
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