Basic Sciencemoderate evidence

Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice.

Nature communications·June 6, 2026·PMID 42251040

Why it matters

Identifies a novel calcium-driven aging mechanism and repurposes mianserin as a potential senotherapeutic, offering a new target and drug candidate for longevity interventions.

Infographic summary of Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice.
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