Basic Sciencelow evidence
Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation.
Nature communications·January 30, 2026·PMID 41617717
Why it mattersFor regenerative medicine and orthopedic specialists, this paper highlights that dynamic, cell-responsive scaffold mechanics may outperform static biomaterials in supporting bone regeneration. It is most relevant as a platform concept for future tissue-engineering strategies rather than as near-term clinical therapy.
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