Randomized Trialhigh evidence
Effect of green mediterranean diet on serum folate and its interaction with genetic variation in folate metabolism: The DIRECT PLUS 18-month dietary randomized controlled trial.
Clinical nutrition (Edinburgh, Scotland)·May 29, 2026·PMID 42269400
Why it mattersThis study demonstrates that a specific plant-based dietary pattern can modulate folate status within the normal range, and that genetic variation in folate metabolism influences both the nutritional response and downstream cardiometabolic benefits, offering a personalized nutrition approach for risk reduction.
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